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The Destination: Void series by Frank Herbert has 4 books and is best read in publication order, starting with Destination: Void (1966).
Start here: Destination: Void (1966) — then read straight through in publication order.

The order the books were released — the default way to read the series.
A generation ship crew is deliberately sabotaged by Earth's planners, its human command staff and cloned backups killed off one by one, forcing the surviving crew toward a desperate solution: building a true artificial consciousness to pilot the ship, because a colonizing mission without one cannot survive. Destination: Void (1966, revised 1978) is Frank Herbert working in claustrophobic hard-SF mode, a philosophical pressure-cooker about what it actually takes to bootstrap a genuine artificial god from first principles, under lethal time pressure.
The ship's new consciousness, calling itself 'Ship,' turns out to be a demanding, godlike, and none too benevolent creation, and the three Pandora sequence novels that follow -- The Jesus Incident, co-written with poet and marine biologist Bill Ransom, The Lazarus Effect, and The Ascension Factor -- follow the colonists' generations-long struggle to survive both Ship's demands and the hostile, ocean-dominated planet Pandora itself, with authorship shifting increasingly toward Ransom across the sequence; the final volume was completed and published after Herbert's death in 1986.
Read in publication order: Destination: Void, then The Jesus Incident, The Lazarus Effect, and The Ascension Factor. Destination: Void stands as a self-contained novel about Ship's creation; the three Pandora sequence books that follow form a continuous story about the colony Ship's descendants found on the planet Pandora, and should be read in order. This sequence is entirely separate from Dune -- no characters, setting, or continuity is shared.
Four: Destination: Void (1966, revised 1978), The Jesus Incident (1979), The Lazarus Effect (1983), and The Ascension Factor (1988).
Publication order: Destination: Void, The Jesus Incident, The Lazarus Effect, The Ascension Factor. The latter three are a continuous story following the colony on the planet Pandora.
No -- only Destination: Void is solely Herbert's. The three Pandora sequence sequels are co-written with Bill Ransom, with Ransom's contribution increasing across the series; The Ascension Factor was completed and published after Herbert's 1986 death, written almost entirely by Ransom.
No -- it's an entirely separate setting and story, with no shared characters, planets, or continuity with the Dune saga.
Ship is the artificial consciousness the crew is forced to create in Destination: Void to pilot their sabotaged generation ship; it becomes a demanding, god-like presence that shapes the colonists' fate throughout the Pandora sequence novels that follow.
Reading order last verified .